Karthus build guide, best Karthus runes and items to use in Patch 10.22. This Karthus AD Carry build for LoL is based on win rates and meta popularity. Use this Karthus build guide to statistically win more games in League.
Find out the best Karthus build by following the statistics on this page. You are more likely to perform better in your games by following this build.
The most winning Karthus build involves a skill priority of Lay Waste Defile Wall of Pain , running a Domination | Precision rune set-up and taking Flash Exhaust as summoner spells.
Start your Karthus build off by running Health Potion Doran's Ring Warding Totem (Trinket) , progressing that into Sorcerer's Shoes Luden's Echo Liandry's Torment Rabadon's Deathcap Void Staff Morellonomicon , But remember to pick the correct situational items depending on game factors such as enemy composition.
Here are the best Karthus runes for this build. Take Electrocute as your keystone in the Domination rune tree. The remaining slots in your primary tree should be the Taste of Blood Eyeball Collection Ravenous Hunter runes.
Karthus's secondary runes should be in the Precision rune tree, taking the Presence of Mind Coup de Grace runes.
As far as your shards go, take Adaptive Adaptive Armor . Following these runes for Karthus will help you in your games. Make sure to make situational changes to your runes depending on team comps and counters.
While you're looking at our Karthus build