Karthus
Karthus Portrait
Karthus
Patch 10.22 AD Carry

Karthus Build and Runes

Karthus build guide, best Karthus runes and items to use in Patch 10.22. This Karthus AD Carry build for LoL is based on win rates and meta popularity. Use this Karthus build guide to statistically win more games in League.

Death Defied
Lay Waste
Wall of Pain
Defile
Requiem

Games analyzed

10,077

Win %

55.40%

Pick %

0.40%

Ban %

7.88%

Kills

8.48

Deaths

7.48

Assists

9.08

Skill Priority (9,381 Games)

Lay Waste
Defile
Wall of Pain
Lay Waste
Wall of Pain
Defile
Requiem
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Spells & Items

Summoner Spells

League of Legends Tierlistgg
League of Legends Tierlistgg

Starting Build (Winrate)

Health Potion
Doran's Ring
Warding Totem (Trinket)

End-game Build (Winrate)

Sorcerer's Shoes
Luden's Echo
Liandry's Torment
Rabadon's Deathcap
Void Staff
Morellonomicon

Runes

Karthus

Primary

Domination

Electrocute
Predator
Dark Harvest
Hail of Blades
Cheap Shot
Taste of Blood
Sudden Impact
Zombie Ward
Ghost Poro
Eyeball Collection
Ravenous Hunter
Ingenious Hunter
Relentless Hunter
Ultimate Hunter
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Secondary

Precision

Overheal
Triumph
Presence of Mind
Legend: Alacrity
Legend: Tenacity
Legend: Bloodline
Coup de Grace
Cut Down
Last Stand
Adaptive
AttackSpeed
CDRScaling
Adaptive
Armor
MagicRes
HealthScaling
Armor
MagicRes

Karthus build in Patch 10.22

Find out the best Karthus build by following the statistics on this page. You are more likely to perform better in your games by following this build.

The most winning Karthus build involves a skill priority of Lay Waste Lay Waste Defile Defile Wall of Pain Wall of Pain , running a Domination | Precision rune set-up and taking Flash Flash Exhaust Exhaust as summoner spells.

Start your Karthus build off by running Health Potion Health Potion Doran's Ring Doran's Ring Warding Totem (Trinket) Warding Totem (Trinket) , progressing that into Sorcerer's Shoes Sorcerer's Shoes Luden's Echo Luden's Echo Liandry's Torment Liandry's Torment Rabadon's Deathcap Rabadon's Deathcap Void Staff Void Staff Morellonomicon Morellonomicon , But remember to pick the correct situational items depending on game factors such as enemy composition.

Karthus runes in Patch 10.22

Primary Runes

Here are the best Karthus runes for this build. Take Electrocute Electrocute as your keystone in the Domination rune tree. The remaining slots in your primary tree should be the Taste of Blood Taste of Blood Eyeball Collection Eyeball Collection Ravenous Hunter Ravenous Hunter runes.

Secondary Runes

Karthus's secondary runes should be in the Precision rune tree, taking the Presence of Mind Presence of Mind Coup de Grace Coup de Grace runes.

As far as your shards go, take AdaptiveAdaptive AdaptiveAdaptive ArmorArmor . Following these runes for Karthus will help you in your games. Make sure to make situational changes to your runes depending on team comps and counters.

While you're looking at our Karthus build

Check out our lane tier lists