Counter picking is key to winning from champ select. Find out the champions that Vayne counters or loses against in both lane and full games.
In AD Carry, Vayne is strongest versus Swain and will win ~55.3% of games. Vayne also counters Karthus , Heimerdinger and Taliyah
In AD Carry, Vayne is weakest versus Yone and will lose ~54.06% of games. Vayne is also countered by Aphelios , Varus and Kalista
While you're looking at our Vayne build